For Partners
Contact Us

Research on ePST®, together with extensive data supporting live problem-solving therapy, indicates that ePST can effectively treat depression.


Users Respond Favorably to ePST


Five clinical studies of ePST resulted in an overall 49.6% reduction in depression. Users readily accept and respond favorably to this form of treatment delivery. ePST facilitates a therapeutic bond nearly equivalent to live therapy.


Engaging, acceptable, and reduces depression

In a small randomized controlled trial at Beth Israel Deaconess Medical Center (BIDMC), participants found ePST to be a highly usable, acceptable, and credible means of receiving problem-solving treatment. All participants randomized to ePST completed all 6 treatment sessions and showed improvement in depressive symptoms.

Works as well as LIVE therapy

In a subsequent trial at Dartmouth-Hitchcock Medical Center (DHMC), 23 completers of ePST showed reductions in depression comparable to results of problem-solving treatment delivered by live therapists.

87% Remission

After using ePST, diagnosis of major depressive disorder dropped from 80% to 11% of the sample in the DHMC study. The completion rate was 80%.

Effectively treats depression

In a third study, also at BIDMC, participants randomized to ePST showed significantly greater improvement in depression than those in the waitlist group. Of the 25 participants randomized to ePST, 100% completed treatment.

Student Veterans

A study of student veterans at the University of North Texas found that ePST produced significant reductions in symptoms of depression, posttraumatic stress disorder, and insomnia.

Older Adults

A pilot trial showed that ePST was feasible with older adults and produced meaningful reductions in depression symptoms.


These trials, together with the extensive research on live PST as a therapy for depression, indicate that ePST can effectively treat depression, and that users readily accept and respond favorably to this form of treatment delivery.


Many Thanks to Our Research Partners

  • Jason M. Holland, PhD, University of Nevada Las Vegas: ePST for Geriatric Depression.

  • Daniel J. Taylor, PhD, CBSM,  ABSM, University of North Texas: ePST for Student Veterans.

  • Luis Sandoval, PhD, Beth Israel Medical Center

We welcome additional research partners, please contact us for more information.


Bedford, L.A. et al., Computer-guided Problem-Solving Treatment for Depression, PTSD, and Insomnia Symptoms in Student Veterans: A Pilot Randomized Controlled Trial, Behav Ther (2017), doi 10.1016/j.beth.2017.11.010.

Sandoval, L.R. et al., 2017. Randomized Controlled Trial of a Computerized Interactive Media-Based Problem Solving Treatment for Depression. Behav Ther, 48, 413-425.

Berman, M.I. et al., 2014. Feasibility Study of an Interactive Multimedia Electronic Problem Solving Treatment Program for Depression: A Preliminary Uncontrolled Trial. Behav Ther, 45, 358– 375.

Cartreine, J.A. et al., 2012. Electronic Problem-Solving Treatment: Description and Pilot Study of an Interactive Media Treatment for Depression. JMIR Research Protocols, 1, e11.

Cartreine, J.A. et al., 2012. Using Self-guided Treatment Software (ePST) to Teach Clinicians How to Deliver Problem-solving Treatment for Depression. Depression Research and Treatment, 2012, article ID 309094, 1-11.

Cartreine, J.A. et al., 2010. A Roadmap to Computer-based Psychotherapy in the United States. Harvard Review of Psychiatry, 18(2), 80-95. Related publication.

Carter, J.A. et al., 2005. An Interactive Media Program for Managing Psychosocial Problems on Long-Duration Spaceflights. Aviat Space Environ Med. 76(6 Suppl):B213-23. Related publication.

Holland, J. et al., in preparation. Electronic Problem-solving Treatment for Late Life Depression: A Pilot Study.